I remember the first time (I'm pretty sure) that I played Fallout 3, I charged at that Mega-Mart, opened fire on the bandits through VATS with an assault rifle-- and burst into hysterics as some random bystander ran through and got cut down by my bullets in slow-motion.
Is is funnier in Fallout 1 and 2 when you are in power armor and a group opens fire with miniguns. The cut down half of their buddies, but you are completely unharmed.
I once lost Dogmeat during the attack on the Super Mutant base with Brotherhood of Steel support(FO1). Dogmeat decided to bite one of the mutants in the
ballsack(oh wait, they don't have any), when the BoS paladins decided to go full-auto with a minigun. They missed the mutant. What made it worse is I always take the Bloody Mess trait.
Of course, I quickly sniped the mutant. (Finesse trait, plus a whole lot of perception and a good gun skill makes eyeshotting things easy.)
EDIT: My last death.
It's hard enough trying to bring in a pirate's ship for salvage/bounty. But the police still shooting the guy with heavy missiles while I still have him in my tractor beam is just ridiculous. Especially when they miss...
Ad Astra. The start is a pain enough in the ass when the only economically viable option is salvage, and with the starting Taipan, that means only the smallest(and throughly blown up) ships can be taken.