Realm Grinder is an idle game, so you don't actually die, just lose progress.
I just ascended to ascension 3 (reincarnation 152 right now, it starts at 150). That means everything is more expensive, research (powerful boosts for that part of a run) works different again, and I need to unlock new powers to deal with the increased prices. My current goal is to buy a power (for a single coin!) that requires me to collect 1e18 spells cast (takes a few hours), 1e7 clicks (the right build can get over 160 auto-clicks per second, so this takes *some* time), 1e64 faction coins (I managed to collect 1e53 in only 9 hours, so...), and never have more than 350,000 buildings (I choose to build those, and can easily stay around 300k) or over 1e17 assistants. Assistants each give me part of my base production *and* faction coins each second. They are what I need to complete this challenge, which is a problem when there's a maximum.
As I said, I managed 1e53 faction coins overnight. This isn't anywhere close to what I need (1/1,000,000,000th), so I took a research that is supposed to be part of the recommended build for this challenge. Immediately, 2 of my random spells both increased assistants, giving me 4e17 assistants instead of the ~e14 I was staying safely at, and locking me out of the challenge for this entire run. maybe 2-3 more hours before I can reset and try another run, because each run has a higher score you need to reach to restart. I've failed 3 times now, and need to go looking for new solutions.
Edit: I had to use Discord (which also feels like a loss), and when I was finally able to spell things correctly (the cursor moves around while I'm typing, because something keeps trying to load, because Disqus is so badly programmed), I learned that I need to get at least those numbers, and the word MAX in capital letters means I want at least that many, not that it's some sort of maximum.