I am floored by the effectiveness of whips. Pretty much any solid hit to the head is a killshot, and other locational damage typically causes extreme pain or nausea. The only reason my most recent adventurer died was because the cheiftain I was up against had an iron scourge. The main downside is the lack of severs or any real bleeding, though I haven't tried a scourge with decent skill yet. Otherwise, a bladed weapon skill + wrestling works well. Take weapon, strangle, stab face.
In battle I always go for the ranged attackers while my companions take on the main force, and then I handle clean-up. For the nastier beasts it's more a war of attrition, though the night beast spouses typically only take a single solid attack to finish off.
Try a pick.
I'm sitting here, wailing against an unconscious giant i downed, swinging away with my axe, then my hammer, then my spear, then my sword, then my flail, then my shield, then my foot. I take out the bronze pick I had stashed, thinking that it could be a useful armor breaker.
1-shot, through the skull, instant-kill.
Since then I've adopted it for everything, and find that:
If you hit them in the upper body, they are torn/shattered.
If you hit them in the lower body, their guts are spilled.
If you hit them in any of their appendages, they sail through the air.
If you hit them in the head, either it sails, or it is shattered.
That fucker is devastating, and it's major draw back is that 50/50 it gets stuck, though that might be because of how DEVASTATING it's hits are.