I really like Dwarf Fortress, despite only having played 4 times up to now (and only in dwarf mode). However, I think that there are quite a few possible simplifications for the player in the interface.
I have seen people demanding more complete/complex management screens, and that is one part. But the other part is making the existing interface simpler to use.
One example that aggravates me often is the switch between +/- and up arrow/down arrow between screens. Why do I need to use one or the other, when there is no second option to take up the other keys? For example in the nobles screen, one has to always use arrow keys, and can't use the +/- keys. Most workshop/building tasks however only allow the +/- keys, most probably because the map keeps scrollable to select stuff. In some of them that could be nice (like when building a workshop), but why would I select a different location while choosing stone boulders for a bridge? Additionally, when currently choosing a workshop from the list, there is nothing to place at all, so moving around is somewhat irrelevant while doing that (all placing happens in a separate screen when building (but not for designation and storage/waste areas)). Same thing goes for many screens, forcing one to remember every screen's favourite keys to navigate it.
Don't get me wrong, there are certainly less intuitive ASCII games, but that's no reason to copy them.