WIFOM Mafia:
A gathering of the richest nobles in the land goes awry. It seems some villians have poisoned the wine. This is very rare magical wine that keeps the extremely aged nobles alive, so they must drink a glass of this wine every day to survive. Every night, the villians poison as many glasses as they choose. During the day, the nobles discuss matters and may freely switch glasses as often as they like, as long as both sides are willing. However, everybody MUST drink a glass.
The nobles have some tricks of their own. They might be able to poison their own glasses, they might have some anti-venom they can use, or they might just simply be able to watch one of the glasses to see who gets near it. There are also dastardly third-parties that have some tricks up their own sleeves, as well. There might be a lyncher who know's if their target's glass is poisonous or not. There might be a serial killer who can make a loud, attention grabbing explosion. During the panic, he has just enough time to switch a pair of drinks or poison one of the drinks without anybody noticing. One of the nobles may even have a special additive that will make the drinker become very submissive, almost as though they were in a cult.
Just an idea I had, but it seems fun. It seems very anti-town right now, so I'd probably throw in a good number of power roles. Take note, however, that there will be no town roles that can find a person's alignment directly. Watchers? Yes. Trackers? Yes. Cops? No. Role cops? Fuck no. Radioactive friendly neighbor? Are you kidding me?
Also, notice that the town has no way of killing people directly (there's no lynch), so I'd also make sure to throw in a good number of town-based killing roles.