I'm mentally and physically male, but there are times when with it would be possible to be the other sex temporarily.
Also I tend to internally blame my anger issues on my testosterone, so I sometimes wish I had less of it.
Inb4 somebody tells me it doesn't work like that.
Anger is controlled by estrogen.
First, I am excited for the day when Transhumanism is acceptable in general, and fundamental-level body tweaking is possible. It'd be nice to have a body or two to wear when I go out. Or even just to be able to tweak some things about the one I've got.
Second, as someone who's had a few years experience with either set of hormones in their body and brain:
Androgens make you feel somewhat more confident and self assured. They make you more impulsive in your actions. They make your metabolism run faster, increase how much food energy is stored as muscle instead of fat, and make your body warmer. They suppress nausea from motion sickness, and maybe in general. They make you think about sex more often. Both Testosterone and Progesterone act (at least in part) as Androgens.
Estrogens make you feel more level-headed. They make emotions hit harder and more intensely, but make processing them relatively easier. They make your body relatively energy-conservative, make waking up harder, increase body fat, and make maintaining muscle a bit harder. They help with empathy, help with noticing or thinking about the other people in a given situation, and make self assurance more an act of willpower than an automatic reflex.
It's all anecdotal experience, and might be colored by being relatively Male Bodied and Female Brained... But them's some things for consideration!
Apparently the Human Rights Campaign are responsible for Coming Out Day. They're apparently the only LGBT organization that routinely throw trans-folks under the bus, and lobby for laws that benefit Homosexual folks, but ignore or are regressive toward other queer groups. They're doin' it wrong. :I
I hope folks don't feel pressure from the holiday, to come out before it's safe or they're ready. If they are, I hope it gives them courage!