You only launch 100 nukes so that one of them gets trhough point defenses.
It only takes one hit to destroy a ship. No material we know of can withstand point contact with a 20 megaton blast. The ammount of lulz in this thread is incredible. Before I go further, let me point out to whoever used it as a source on lasers, projectrho/"Atomic Rocket" is probably one of the greatest sites ever made. You all really need to go read it before talking about realistic
Lasers: Anything in the higher frequencies is perfectly tight beamed at long range. In fact, just for gratuitous lulz -- I'm sorry -- I worked out the effectiveness of a CRASER, or cosmic ray laser. tl;dr this weapon has targetting data limited range. Firing from the sun, it could snipe the hairs off a human head. This is with ONLY a 4 meter radius reflector. Of course, UVRASERs, XRASERs, and GRASERs are less effective, but all are capable of multi-light second damage. In fact, many times you want a LESS foxused beam, as it means you can hit a target even if that target has moved, as well as you don't need to keep the laser on target for as long.
Nukes vs Pod: If you can hit it with a nuke, you cannot nessicarily hit it with a pod. Nukes are small. They can have accelerations no human would survive. By very nature of their size they are extremely difficult targets, and require far less thrust to accelerate.
Army vs boarders: If you oponent employs boarders, you employ marines. That is, assuming, that a lightly armeored and fragile, yet large object can ever reach your ship.
Disabling: Yes, this is an effective idea. By boarder any non-vaporized wrecks, you can gain insight into technology and many other things.
Onship combat: First of all, its rather easy to scuttle a space ship. Drop the safeties on the reactor. Second, you cannot employ gas against a compartmentalized target. They can suck it out, or more likely, they're wearing suits.
Mass: The mass of an anti-personnel weapon is neglibable compared to that of even a SMALL ship-to-ship weapon.
Anyways, on topic; The game looks like it will be plenty of fun. Want to try it when it comes out.