Has there been any indication that a supernatural consciousness capable of manipulating reality exists?
There's plenty of anecdotal evidence. There are also many people, even some well-respected ones, who insist there is. Does that count?
Anecdotal evidence is not actual evidence. Nor is insistence, so no.
Of course, that doesn't mean you can disprove that a god exists, and no one will ever be able to disprove that (although many things in various religious texts can be and have been disproved). Still, the burden of proof is on God or anyone who says God exists. The fact that a thing can't be disproved is meaningless, as there are an infinite number of completely absurd things that can't be disproved which no sane person would suggest truly exist. This is the purpose of the Flying Spaghetti Monster, an intentional strawman argument meant to show that the belief in God because it can't be disproved is ridiculous.
Some say that it's foolish to state flat-out that God doesn't exist, since one cannot prove that statement. While there is some logic to that, the same could also be said of the Flying Spaghetti Monster. And in any case, the trend of science in history has been to remove the need to explain physical phenomena as a manifestation of God's work. All throughout history fewer and fewer things have needed a divine explanation, and the scientists who thought that newly discovered inexplicable phenomena could not be explained without God have always been proven wrong later. They simply lacked the tools or the motivation to go further. This happened to Plato, Galileo, and even Newton.
This trend has never reversed, and taken to its conclusion, suggests that there is an explanation for everything, even if that explanation is beyond our abilities, and none of them require the participation of a God.
And, to be honest, the imaginations of the people who wrote the creation myths are put to shame by the wonder of what we have discovered through science. The stellar life cycle and geologic history of the earth are far more fascinating than Genesis, with enough branching storylines to keep one entertained (or occupied in study) for a lifetime. Next to what we know about the universe so far, God is just plain boring as an explanation. On the one side, you have self-assembling gravity-powered chemical factories that produce everything we know, then shut down in titanic explosions, sometimes seemingly breaking the way we used the think the universe should work, whose byproducts condense into planets and eventually are assembled into us. On the other side, in summary, A wizard did it.
Meh.