I'm terrified by the ammount of micromanagement required to play DF. What's worse, it seems the situation is getting worse with each update. I can only guess how will the next version work, but I suppose the hospital setup, burrows setup, army equipment and deployment, etc. adds more micromanagement to the game.
Don't take me wrong. I love that I can set things like individual weapons, safe zones, etc. But I shouldn't be required to. There should always be a default option that works without the need of player intervention.
Take military, for example. Right now, when I draft a dwarf, I must set his weapon and armor preferences manually. That is micromanagement. It would be better if the game automatically equipped him with someting (depending on material, item quality and personal preferences). I should only set the weapons manually if I want to do something special, I shouldn't be required to do that.
Or a different thing - labour settings. In the current version, dwarves have only one job by default. I recently tried to play the 2D version and was surprised that the dwarves always came with all the jobs in a single group enabled. That actually worked better - the fortress worked and I had no idlers even if I didn't change the settings. With a whole group enabled, the dwarf could easily find something to do. If I wanted to specialize my dwarves, I could open the labour preferences and change them - but I wasn't required to (and in the end, I didn't change most of my dwarves... while in the new version, I tend to change all of them). Newer versions have this the other way around, which feels kinda contraproductive and makes the game needlesly more complicated.
These were just two examples, but they illustrate my worries about the user-unfriendliness, which seems to be getting worse.
EDIT: The 2D version as a whole feels more streamlined and user friendly.