The dumbest thing I've done so far was set the littersize of dogs to 200. At the time I needed tons of bone for practice bolts and my already large population of dogs weren't producing fast enough, so I figured I'd have them make more of the bastards. The first batch of 200 came in and I immediately set them all to be butchered. My five butchers and five slaughterhouses were done with about 15 puppies when another dog gave birth to 200 more puppies. I exited and fixed the raws back to normal so I wouldn't get any more of the fuckers, then set the next 200 to be butchered. After a few minutes, I noticed all my workshops were at the higherst level of [CLT] with about 60 bits of puppy each. There was no way my haulers would be able to work fast enough, so I deconstruced each workshop and rebuilt it every fifth puppy or so to keep them at least 50% efficiency.
I was done with about a third of the puppies when the whole third level of my fort suddenly turned into a giant purple cloud -all of the puppy tallow and puppy meat and meat chunks and puppy skin were rotten or becoming rotten, and some of the rotten puppy bits had already been hauled off to stockpiles and dumps. It took about 15 minutes to wall off the butcher's workshops and the dump and to get all the puppy chunks out of the stockpiles. Eventually I got bored of demolishing/rebuilding butcheries, and I just let them get cluttered and run at 10% of normal speed.
By the time the butcheries had gotten rid of about 350 of the 400 puppies, it had been an entire year, the butchers, bonecarvers, and tanners were legendary, and now I was butchering dogs instead of puppies. When the original 400 puppies, their puppies, and the puppies of other random dogs that had been born during the year were finally done away with, I had no idea what the heck I was going to do with all the crap. 2000 bones, 2000 chunks, 2000 meat, 400 fat, and 400 skins, and 400 skulls from the original 400, and some extra from the others. The rotten meat and bits and fat were still being atom smashed by a bridge I built next to the butcheries for that purpose, I had 3 legendary bonecarvers making thousands of bolts out of the bones, about 80 of the skins had been tanned and were now lying around gathering dust, the rest of the skins were rotten and in the atom mash queue, and the skulls were sort of just lying around cause skulls are cool.
So the moral of the story is you really shouldn't edit the raws so you get 400 puppies because it's fucking retarded, but you'll get a mountain of puppy skulls so it all turns out okay.