Fighter: Now starts with a Potion of Might and higher quality weapons.
Gladiator: Now starts with higher quality weapons and throwing nets mulch instead of decaying.
Skald: Song of Shielding no longer exists, Song of Slaying has been buffed.
Transmuter: Sticks to Snakes no longer works on clubs, spears, etc. Just ammo.
Warper: Portal Projectile now gives smite targeting on weapons for a duration instead of for one shot.
Wizard: Repel (and Deflect) Missiles has a chance to expire every time you're shot.
Summoner: Loses Summon Scorpions, gains Guardian Golem (it casts Injury Bond) and Lightning Spire (It casts Lightning Bolt) instead.
Conjurer: Fulminant Prism and Iskenderun's Battlesphere have had their spell levels swapped.
Air Elementalists: Swiftness now causes slowness when it expires, duration equal to duration of swiftness.
Wanderer: Now starts with slightly better skills and equipment. Still awful.
All Spellcasters: Now start with more Spellcasting.
Felids: Can now jump at people and use wands.
New Species: Vine Stalker and Formid
Vine Stalker are plantmen who have Spirit Shield, antimagic bites and troll regen without the troll hunger or armour penalties.
Formids are antmen who can dig at will, see monsters through walls and use shields with two handed weapons. Cannot teleport or be hasted.
Spears, daggers, clubs, and hand axes are no longer throwable.
Potions of Slowing have been replaced by Potions of Lignification, which turn you into a tree.
Elven/Dwarven/Orcish equipment no longer exists. Beogh blesses all shields/armour but not weapons.
Curse Scrolls and Potions of Blood only exist in vaults/if created by a player.
Most of the old Rods were replaced.
New Temple God: Dithmenos.
Dithmenos gives a stealth aura, the ability to teleport next to people and the ability to turn into a spoooky ghost. Hates fire, loves stabbing.
Cheibriados had his first ability (the slowing one) moved down a star.
Nemelex no longer cares what you offer when gifting! Decks are fixed at 40% Destruction, 30% Summonings, 20% Escape, 10% Wonders.
In tiles, you can use Ctrl+Left Click to autocast your last cast spell (if applicable) at the monster you click on. No idea if this is new, but I only just found out about it, so I'm posting it anyways.