I'd be more worried by the amount of "boxes" they feel they need to tick. For example, the original artist is transmale, so I'm pretty sure they're going to feel obligated to put some gender-fluid stuff in there for at least one of the major characters. And all the other little cultural nods they think they need to reward the demographic that's probably their core backers. Now, these aren't bad things, but they objectively whittle your core audience down little by little. Just teabagging all skeptics seems to be the current strategy instead of listening to other people.
There's also the question of how they're going to balance anime-style serial structure vs western-style episodic structure, and how many episodes they're going to schedule this thing for. If they're brave, they'll go for an almost 100% serial structure and structure it entirely into story arcs, since if you're trying to capture the anime feel you need all the help you can get. Since it's on a streaming service, and not on TV they can get away with not having to have an episodic structure. So this is one area that they could in fact break away from some of the constraints of those "CalArts" type shows. If it turns out to be entirely made up of 12 minute self-contained episodes, I'd be -_- because they just didn't get it.