It's always amusing to wander into a new town, take a single step, and then receive a message about the mayor losing his grip on his left boot and sock and falling over. The game still apparently equips world gen creatures with appropriate gear even when they don't have a limb to wear it, resulting in lots of "I just realized my arm's off, whoops there goes my glove and shield" incidents. I once wandered into a town where I got two screens full of stun messages, but nobody seemed to have been damaged or wounded when I talked to them.
My favorite anecdote regarding world gen creatures not realizing something is wrong with them is when I tried to play a race of sharkpups (sharks mixed with puppies that walk on land). There was a bit of an... oversight in their creation. After hundreds of years of expansion and dominion over the lands, I started a sharkpup adventurer, and it went a little something like this:
Stakud Cattenhob, Adventurer: "My friends and family, I bid you farewell. I am off to make my fortunes in this world and bring glory to our mountain home!"
Shorast Fashadil, Peasant: "Stakud, wait!"
Stakud: "Yes, Shorast?"
Shorast: "I just realized something. Don't we need water to breathe?"
Stakud: "..."
Shorast: "..."
The reign of the sharkpup came to a very abrupt and very Wile E. Coyote end.