What made me stop playing DDA were the changes to nutrition together with the removal of mods like "easy nutrition", which I already considered an essential to play even before the obesity / stomach volume changes. For one thing, the changes are touted as "realism" while being unrealistic as anything, for another the interface simply does not support the information necessary to make it work.
A pet peeve already before these changes were the "frozen food" update. Apparently eating frozen and then re-heated pasta dishes is awful enough to make one contemplate suicide in a zombie apocalypse. Strangely enough my wife freezes leftovers from her pasta dishes regularly, and they are delicious after being re-heated, but hey, what do I know, DDA realism experts know best, so I'll just go and shoot myself after the next meal
And I agree with King Zultan, the sci-fi stuff was fun, interesting, and followed the lore. Now everything is being retconned away, and while some parts of the game got definite improvements I'd really like to experience, the overall effect is bad enough to make me not play the game at all. I haven't tried Arcana or Bright Nights yet, maybe I'll give one of those a whirl.
At one point I even considered contributing to the project (my day job is C# dev), but holy heck is that GitHub a cess pit of favoritism, insults and circle jerk. If my work place was like that I'd try to get the responsible people out of there, and if that fails, quit myself. No way I need to expose myself to that in my spare time.