To be honest barring a few hurricanes (none of which were major; in spite of my northeastern origins I feel qualified to discuss what a major hurricane is), the coronavirus was the very first crisis the administration faced that was not of its own making.
Man, I say this with as much respect as I can, but fuck off with that. A cat five fucking bumrushed the florida panhandle in 2018, and we're still picking shit up from it two years later. The scale literally doesn't get more major than that. Pretty sure Harvey hard fucked texas a year or two earlier than that, and I think I'm forgetting at least one more serious hurricane for this administration. The crow plague isn't even remotely the first crisis not of their own making the shitgibbon's faced and been found hella' wanting in relation to.
And yet in spite of it Florida still exists, which is the real disaster.
Right well I underestimated Harvey a bit and I'll retract "major hurricane" but let me reemphasize: I said crisis, and in the grand scheme of things hurricanes are not really a crisis in terms of what an administration actually does unless it's a very unusual incident. Most of it is handled by the "automatic" sections of government, i.e. FEMA. The President, and the White House as a whole, is by-and-large not required for their decision-making capacities during those events. How well organized the federal response is, how well-funded, how thorough; these are things that flow almost exclusively from systemic (i.e. funding, leadership, the training and administrative skill of the organization) factors, and while the administration has a huge impact on those, it's only a crisis if there is some sort of unusual failure there (i.e. Katrina, or in fact Beirut's explosion).
If it's just "this is a horrible ongoing thing and many people have been hurt and killed and"... well that's just everything nowadays isn't it? Opioid epidemic, infrastructure failing, etc. etc. etc. Crises, as I'm defining them, are something unusual, long-lasting enough that political decisions have visible effect or lack thereof (yet, sharp enough that it seemed to come all at once). From the OPEC embargo, to the financial crisis: the distinguishing factor is high-level decision-making. Which, most of the time isn't really all that important as all the other more boring stuff like the secretaries, the legislation, the departments, etc. But sometimes it matters.