Currently Demons, boogeymen etc. are bound to evil spheres like darkness, death, horror. And good creatures are biased to Light and Life spheres. Is it possible in the future M&M mechanic to have the opposite? For example light creatures are terrorizing common folks and dark creatures are good and helpful.
It seems likely, especially for light and darkness, since those don't really have any intrinsic moral aspect to them, we just associate dark with evil because [dark = can't see = scary dangerous things], and light banishes that darkness. Darkness could easily be good and helpful, and light could easily be bad (see 90% of all JRPG's, and also Bayonetta).
Some spheres seem like a challenge to make them vary between worlds though; take the spheres "misery" and "torture" for example, how could a being representing those be anything but evil and hostile? Their very association with those spheres implies gaining benefit from/spreading/proliferating misery and pain, which are inherently negative for anyone who experiences them.
It's way easier to twist "good" spheres into being evil though; "happiness" for example, but at the cost of all other values; you could imagine a happiness demon that wants to make everyone into mindless lotus eaters with no concerns about anything that happens around them.