Rad storms are brutally lethal. I've yet to have someone caught in one survive, there's just no way to save them. And if you're in a biome where they happen, they happen hideously frequently - you need to rush underground as soon as you can, which majorly restricts your access to vital junk.
EDIT: Brewing liquor doesn't actually do anything to extend your drink supply, since creating booze consumes as much water as the amount of booze it makes. If anything, it just splits your water over multiple barrels. I suppose it does at least generate pleasant thoughts thanks to inebriation.
EDIT2: Just noticed - female hivers are being generated with facial hair. Didn't realize until I decided to play around in adventure mode and ended up generating an Escher lady with a neatly-combed mustache and beard. Went digging in the raws - looks like females are being assigned facial hair layers, and males are ending up with MULTIPLE_LITTER_RARE. Looks like some switched orders, like the problem that male and female eschers were having. Goliaths were also having trouble with the improvements meant for males being handed out to female goliaths, and the extremely reduced combat skill rates being handed out to ALL Goliaths, overwriting the bonuses males are supposed to get. Was able to fix most of them by fiddling with the orders in the base Rubble files.
EDIT3: Flavor note: The current description for Redemptionists is 'A person entrusted with enforcing the harsh and merciless law of the Hive.' The Redemptionists are an outlaw cult, so this seems probably incorrect? Although, on the subject of law and order... one possible endgame threat to implement could actually be the Arbites, who are generally significantly better armed and equipped than any of the groups underhive. Arbites have access to actually good armor and things like lasguns, autocannons, and even bolt weaponry, which would make them a suitable challenge for a well-established hive. They did get Necromunda rules, even.