About to do my fourth reset. My first run was looong, maybe a couple of weeks? I still have the save, it was past the year 2000 at least. I had one of each space facility though! It was before the kerosene update which in some ways was easier, once you got the oil limit high enough anyway.
On my second run I wanted to take the advice and reset at concrete huts, but I didn't like the thought of slogging through all that compendium crafting again so soon... I'm not sure I've reset without unobtanium huts yet. Probably not optimal, but eh... The space stuff is neat!
(Plus one cryo-storage on terminus)
Here's what my setup looks like pre-reset. It's an absolute mess because I spent 250 paragon on the weird-named 2% ratio upgrade. Managed to get 32 more kittens from that, so partially recouped! I should farm mansions for a while longer, but I'm really sick of crafting steel. Even though I can get it fast from trading with spiders and zebras. Hence my crazy-high catpower production. As high as it is, I actually barely trade fast enough to use up the gold my geologists produce!
The ratio upgrade actually didn't allow me to build a single additional space station, because the loss of paragon hurt my science cap a lot.
The ratio upgrades make things so much faster. And after run 2, I've learned to keep some paragon around for the production bonus. Though the benefits diminish rapidly past 150 or so. The real benefit is to storage size, but for right now the ratio upgrades are probably more important.
Total paragon: 534. I reckon that, since karma gain diminishes with higher population resets, my karma is probably relatively low compared to my total paragon.
... Oh hm, I forgot to do a mission to Kairo. Even with my paragon it was going to take me 5 hours worth of kerosene, though... Maybe another time. I don't actually know what's there, it wasn't there before. Mystery :3