What killed Skyrim for me was a congregation of several things. First, boobplate. I hate boobplate. Second, the voice acting. Faux nordic accents spoken in a dull, lifeless tone. Third, the magic sucks. Fourth, for all the talk of a civil war there does not seem to be a lot of waring going on. Fifth, the combat is dull and repetitive. Sixth, overpowered stealthing is overpowered. Seventh, the main storyline was meh. Not entirely despicable as some claim, it's just that a lot of the storytelling was dull and lifeless, like the voiceacting.
Given what we've seen of fallout 4's gameplay, I have high hopes in the boobplate (or the lack thereof) department, the combat looks solid, and there's no magic system.
I can't comment on the voiceacting because of how little we've seen of it (though that robot seemed good enough, the protagonist also) and stealthing will probably again be OP.
As for the story, given that this is Bethesda, I predict a story that starts off interesting and builds up a modicum of intrigue or even action but then devolves into trite cliches and plot twists and ends with a far-too-neat-and-predictable a resolution. Surprise, the Institute turns out to be the Enclave. There'll probably be some interesting sidequests tho.