I think that the game looks pretty great, aesthethics-wise. One thing that was true for F3 was that they certainly worked very hard to reproduce the look of the old fallout games, sometimes to a ridiculous level. F4 looks - from the little we've seen so far - like it wants to establish itself a bit more, appearance-wise. This is not bad in itself, although there's iconic stuff I would enjoy if it remainined the same. If we talk purely "graphic level" them it of course looks superb, but then again I assume it is played on Beth's gaming super computer to give it that way.
However. It also has lots of little things that are very "bethesdian" in that they've been in almost all their games since-and-including Morrowind. They've gotten better for each game but they're still there - people still walk like they're stuck on a stick bound to a rail or something, for example. And that they just upgraded the looks without dealing with these... I'm not sure what the word I'm looking for is... These little annoying things that's been with them for so long, that's a bit grating.
ninja'd
Also it's an urban area devastated by bombs, like the capital wasteland was. I'm really excited about that actually. New Vegas was a great game but my favorite part of the series is nasty blasted ruins. New Vegas was too developed for my liking. Maybe I'll enjoy building something out of the rubble myself though.
But the Capital Wasteland looked nothing like an area devastated by bombs. At least not to me.
One of my favorite changes in 4 is actually the fact that they got rid of the skills system, because while it makes a LOT of sense in a turn based game, it doesn't so much in an action RPG, again, impo.
I'm not sure what you mean. I'd agree that it fits a highly action/shooter focused RPG better, but I have no idea why lockpicking or science or repair etc would work better in a turn based game than a realtime one.