Well, it seems that the Star Control 2 game with my pen&paper buddies is happening (someday). I asked everybody and they appeared willing to do any genre, including hard or soft sci-fi.
So now, I'm gathering some data from my memories of the game and the intertubes, got the basic "endgame" (I looked a walkthru and it all boils down to "blow up the Sa-Matra!" - tho a different conclusion would be possible, if the players are clever enough to come up with an alternative and succeed at it). Other than the required items (a bomb, freeing a certain species from a shield, and safely acquiring a Talking Pet) pretty much everything else would be open ended.
I'm actually going to expand it a bit backwards, with a "prequel" sequence/adventure/"tutorial?", where the players find out and activate the Precursor factory in Unzervalt, then fast forward to 15-ish years later.
I'm not sure how I'm going to handle space combat - I'm thinking just using regular skill rolls to either use multiple Flagship systems, which should have enough guns or whatever for all players whenever they just want to straight-up shoot, and of course pilot escorts that they've acquired. I know that I'll have to add face-to-face encounters somehow too, I suppose it will be about 50%/50% whenever some MacGuffin location is visited.