Tried on two PCs today - does not crash! I'll keep trying...
What tileset/overrides are you using? Also, when disabling TWBT, are you setting print_mode to 2D or STANDARD - better set to STANDARD because 2D is too different. Maybe other plugins you're using interfering?
I've been having the same exact problem. In fact, I registered here tonight just to give this info after quite a few years of lurking around here.
Randomly crashing when - resizing the screen (very rare) , clicking to build a workshop, clicking to build wall/floor as well as moving the cursor to do either of those.
Originally I thought the wall/floor thing was my resizing the selection as I was moving the cursor as I seem to recall that happening once in a blue moon on earlier 4x versions. However, one particular day I crashed several times in a row trying to build the same workshop in the same tile. I even rebooted to see if maybe there was some unreleased memory hosing something up but it did not help. As a test, I built something else and went back to the original and was able to place it fine. In fact, it did not crash on me again for a few hours.
After switching back to Standard I have had 3 full, solid days of the game running without a single crash. In addition, framerates have been capped at 100 for almost the whole time.
Not to pile on, but I can also say that for the first time since I installed .06 I have not had the ghost/missing caravan problem. This one has been a major problem for me, either popping up immediately in the 2nd year or the 3rd.
I have tried TWBT and the Legacy option with the same crash problem. The starter packs r02/03/04 with tile set Phoebus all had the same issue. Plugins active are Other Automation plugins, Performance Tweaks and Workflow. I have turned them off and experienced the crashing.
I don't mess with the files or launch options too much and I had completely forgotten about TWBT. Part of the problem using the LNP I guess. Once I turned it off, all the problems stopped. I hope this is something that can be tracked down and fixed. I've become so used to seeing the game this way it's hard going back.