I try and save and it crashes immediately. Attempting to start a new fort in a previously used map causes the game to hang for a significantly long time and eventually crash/no-respond. I know it takes awhile to load a map sometimes, but I'm talking about letting it sit for 10+ minutes (my computer is just shy of super-computer in power) before calling it dead. I've had a few other CtDs too, though they seem a bit more random.
Actually, when I went to start the .2 Human Fort release I first have to fix a graphics issue. The 16x16 Phoebus graphics were mislabeled (png not jpg or something). Not a big issue, just grab the file from one of the 5.10 MW releases, but still.