When it comes to pranking on April Fool's Day, I usually try to keep it fun, and make sure the victims don't feel so victimized (or basically, wanting to kill me after the prank is done). Of course, setting up the pranks and such is becoming more of a chore as I get older, but dismantling others (we tend to setup plenty of traps) is half the fun as well, especially when you out-think the prankster, and reset the trap they made for you, and redirect their own prank at them.
Of course, there are also some classic/traditional pranks we do every other AFD. Amongst them is what we call the "Crazy Kitchen". Basically, while nobody is around or awake, you open everything that isn't powered in the kitchen, and they walk in to see every door and device open. If anything, it works best after giving them a few warm-up pranks beforehand, like setting up a broom or something tall against the crack of the door, so when they open the door up, they get a stick dropped on them randomly. You can also saran the head-level of the doorway for good measure (lightly taped on so they don't get clotheslined; but rather, slowed down).
Most of the day is spent working and such usually (mostly landing on work days is a given), but it's nice to get hit with a clever prank every so often, but when work hours are no more, then back to business. Just as well, family is usually the main target, since we know the routines and traditional pranks. Crazy Kitchen is usually the flare for "Pranking has begun".