Very unlikely, Leo, but only because they have a tendency to have fairly strict formatting guidelines. However, if you managed to construct something that used image macros for all of its figures, you might be able to get away with it. It wouldn't even have to be revolutionary, just well-done and informative. I have no idea how you'd do this, mind. You'd need to be able to convincingly demonstrate that this was a better way to present your information than anything else, and I can't imagine doing that in the context of anything that could be called a serious academic paper.
That relies on the idea that people actually think it's a subversion, which experience has shown me they really don't. May-may June last year showed that, for example, the fine euphoric folks at /r/atheism seem to think that image macros are good communication and that there was no stereotype to begin with.
That suggests to me that they're doing what they would've done with raw text, then. Which is mostly just ramble in an echo chamber. That falls under people doing stupid things with them. I don't think image macros are to blame. A better candidate for blame would be the Internet, for giving them a place to congregate.
In any case, to clarify what I'm trying to say in case it feels like I'm moving dem goalposts, I've got problems with two assertions: image macros (and Internet memes in general) are making our society stupider, and image macros (and Internet memes in general) are inherently inferior ways to communicate. Both of these seem to me like nonsense born out of a desire to feel superior to some other group.
I've got no problems with the idea that many people are stupid at all points throughout human history. I also have no problems with the idea that people rarely make full use of their chosen medium of communication. I also have no problem with the idea that people rarely have particularly deep or meaningful thoughts to communicate in the first place, although
that doesn't make them stupid one way or the other.