I have. I use them on one flank while the other end is a spearwall with the middle a mix of other melee weapons dependent on my enemy. I'll have three, maybe four guys in the backline (2range/2polearm or 2range/1polearm). I have the bulk of my line engage first and have my 2hander go on a flank. Preferably they don't pull anyone since they'd be engaged already, but they can go 1on2 or 3 with my builds. If the flank works well they usually cleave up the line while my shieldwall holds.
As for the guys themselves, they get my heaviest armor, and I get them a greatsword as soon as possible. The new pokin' stick is pretty solid too though. Statwise I prioritize melee attack, hp, ranged defense, and melee defense, but a high roll for fatigue or initiative is a good swap for any of them. On a phone, so I can't look up perks for minimal effort, but they definitely get collossus (everyone does with me though), the ones that increase injury chance and damage to injured dudes, the heavy armor perk, and the one that reduces movement penalties.
Or at least that's what the perks i forgot the names of used to do? I think some got reworked and I haven't paid attention in a while because I keep actually forgetting about changes having happened >_>
Regardless, my company always has one or two 2handers in the field with at least one reserve, but unless I get an unlucky arrowfilled early game my starting 2hander tends to be the last alive, with the others filling in when he's injured.