Presumably you've also already gone over stuff like Torchlight 2?
There's apparently also something called "Last Epoch" that's out in early access, but I don't know anything about it.
Yeah, I've pretty much beaten most entries in the genre that are playable offline to death. You get a
lot of downtime when travelling deep discount. ("You'll give me a free burrito if I accept a bump to a flight next week? SURE!") The downside is that you're usually so tired yet unable to sleep is that anything that requires focus is right out.
Last Epoch's, out of the more recent-ish wave of looty ARPGs, is closer to PoE than anything.
It's main hook is a kind of weird skill tree system, in which you pick a main (and eventually specialization) with its respective passives, have 5(?) skills you can socket that will have their own skill trees. It's actually pretty interesting; for example, necros can choose to build out a golem such that it's an aggro magnet, passive PBAoE, debuffs, etc. A warrior-alogue has the equivalent of Cyclone, but you can use it as a movement skill or a huge one that pulls things in but renders you stationary, etc.
Lemme just name a few that come to mind, from different genres.
Tried Factorio?
Oxygen Not Included gets pretty complex lategame if you want to build liquid hydrogen fueled rockets.
Factorio and ONI are two that I often see lumped together, yet I find they have an
incredibly different feel due to one major difference:
ONI discourages experimentation; Factorio practically forces it on you.
In ONI, it's fairly easy to accidentally cause a cascading failure... I was trying to switch to a new oxygen producing setup that unfortunately had a few design errors. By the time they hooked the old one back up, which should've been trivial, things had already started going into a rapidly accelerating downward spiral. Pretty much every time you'll want to experiment with a new aspect of the game you'll either need an overabundance of resources on hand to figure out how it works, or just assume you're going to crash and burn and make a better one next time. Or look up how you're "supposed" to do it.
Factorio, on the other hand... assembly and disassembly of existing structures is practically instant (especially after early game, where you can automate construction) and there's literally only two ways that resources can be permanently lost that I can think of (and they're very obvious-- destruction, like having a building eaten by the natives or utilization of a consumable... quite reasonably, you don't get to reuse nuclear bombs). Want to rearrange your base due to take advantage of new technology? That'll take you all of 10 seconds. Whoops, realized that you put your supply lines in the wrong places? Pause it, spend an half hour staring at the screen trying to figure out what you meant to do and rearrange your blueprint, then give it another 10 seconds unpaused to watch your construction bots move everything to the right six inches except one belt.
Have you ever tried The Last Federation? It's by the same guys who did AI War and I'm pretty sure it's part of the Humble Trove.
It's kind of meant to be a solar system simulator, and you basically start out as a fairly powerful neutral third party faction that gets to do whatever you want, but ostensibly is to unite the system under one government. Whether that means an allied UN, or mass genocide.