I've gotten back into this, big-time. Despite my gripes with the game and not knowing how to mod them away, I bunged a few new mods in there, archived and cleared up all my defunct save games (as someone mentioned in here, they were really slowing things down as it turns out) and jumped into a new game, with the first three twerps the game generated for me, no less.
Somehow, despite having more stuff to deal with (mainly Dub's hygiene mod), this has quickly become one of my most successful forts. There have been a few massively irritating moments (I really need to add CE back into the mix, but I don't know how many of my new mods are compatible) and for a moment there we were clinging on by a thread, but so far we're still going and our predominantly-wooden base hasn't burnt down. Originally I thought all my mods had bugged the game and I was never gonna get any raids, then I had three or four (small and poorly equipped, thankfully) in a row which we made it through by the skin of our teeth.
Having my colonists need to poop and be constantly running off to compulsively wash their hands hasn't been a big a problem as I expected.
Edit: just had a guy decide to watch the sunrise and wander over to a nice, scenic spot next to a pile of dead enemies to nicely cancel out any good thoughts he might have had about it. (Shouldn't skeletons give at least slightly less of a mood debuff than corpses that are still, y'know, rotting?)
Edit:
Ooh, I'm not sure which mod added this, but apparently there's a cultural expo coming up that we've been invited to!
Unfortunately, this year's host is our closest neighbour, who I've been getting relationship hits with for being too close to them... hmm. If we do attend I suppose we'll have to be packin' some serious heat.