There's very little potential for maintenance tunnels, making it VERY hard for traitors to not be caught and reducing the amount of places where you can kill people/absorb people/draw runes without the all-seeing AI calling it out. On our current station, just about every room has a maintenance acces, but here, only a fourth or so of the rooms could have an acces, and then some of those tunnels would be exposed to space.
Look carefully. Zoom in, if you need to. The only rooms which have maintenance doors on the current build but don't have room for them on the map I made are: Library, Lawyer, Detective, Dorms, RD's office and Custodial. Most of maintenance is out of view due to distance (Quarantine, Toxins) or walls (All of Cargo, all of EVA, all of Engineering most of Bridge, most of Bar, most of Chapel) being in the way. All of it gives you access to asteroids to go hide behind, stash bodies, eat people, draw runes, dig secret bases, etc. where the AI doesn't have cameras at all. The only parts that are really troublesome are sneaking past the bar or into the bridge/security areas through maintenance (but only while being tracked, one you get past you're hidden again). Even then, it's still doable if you use the space suits and a fire extinguisher to leave the catwalks and go into space out of view distance for your nefarious deeds.
Spacesuits everywhere is just a big problem because that's the point of EVA being high-security.
Securing the RCD, magboots, jetpacks and hardsuits, mostly. The normal space suits themselves aren't all that problematic, since all they do is let you go into space. Since going into space on a space station is fun, I'm all for making it easy to do.
Medbay and being spread out will make things very complicated, due to their interdependance, both between these two departments and in each department itself.
If you look very carefully, Cryo, Genetics and the Medbay lobby, the three rooms where you drag dead/injured people, are all right next to eachother. The two bits of medbay that are spread out are virology (which only cares about Chemistry and the CMO anyway) and Chemistry (which is moved between Virology and R&D, the two people that need chems the most). Likewise with science: Toxins (which is just down the hall) and Xenobiology (which, logically, should be apart from the rest of the station) are the only two moved away from the main Research/Robotics core.
Thin glass walkways make cutting parts of the station off by vacuum easy.
One of the major reasons for giving everyone access to spacesuits for space walks.
That said, this would be a very space-focused map, kinda like Gibbed's current cogmap station. Going into space, fighting people in space, protecting yourself from the vacuum and so forth all are a bigger deal on this map.