I seem to recall somebody else posting with almost exactly this same question recently. I believe the answer is no, at least not without making an entirely new tileset.
EDIT: It's on page 208, apparently it is possible to do it manually (with SpaceFox at least), but I'd suggest getting somebody more competent than me to run you through it.
Many many many thanks and now DF looks as I like it. CLA like font (Haowan) and Phoebus tiles. Here's a precise description of what I did:
1. Activate Phoebus via Graphics -> Choose -> Phoebus 16px
2. Copy file
Haowan_Curses_1440x450.png into \Dwarf Fortress 0.42.04\data\art\
3. Graphics->Customize->Refresh
4. FONT=Haowan_Curses_1440x450.png, GRAPHICS_FONT=Phoebus_16x16.png
5. Print mode=TWBT, Truetype=No, DFhack:Enabled (does not work without dfhack)
- You can not use Truetype fonts because of TWBT.
- I've seen flickering screen edges at times and got rid of them by pressing F10 (default zoom level)
- you may want to use other tilesets, depending on your preference and screen resolution,
from the repository. Those have great easy to read fonts:
Cooz_curses_square_16x16.png
curses_square_24x24.png
Haowan_Curses_1440x450.png
Nagidal24x24shadeBeards.png
Oreslam_1920x1200_20x20.png
This is how it looks - and the best is, zooming does only zoom the map, font size stays the same (perfect for me):