Yes, imagine World of Trucks, an online persistent-based MMO trucking game. Imagine having to deliver three trailers for a single high value job and doing it with your friends (who co-own your trucking business or are your employees).
I have been playing with mouse and keyboard since all I have is a joystick but it's working fine so far. This game does require concentration though, as I have made genuine mistake when I was playing this game sleepily. I started from scratch again since in my first run I took the bank loans too early and felt should have built up my skills first.
I'd recommend doing jobs til you are offered 500,000 euros credit limit by the bank and saving up 30,000 euros yourself. My budget consists of:
Upgrading the garage to accommodate three trucks -- 180,000 euros
Buying three trucks with no blings at all (cheapest models I could get) -- 310,000 euros max
Drivers hiring fee -- 3,000 euros
Total costs -- 493,000 euros
That should leave you with enough emergency funds to cover loan repayments (7,000ish euros/day) and running costs (driver wages, fuel, repair, etc.).
Also be careful when driving in the UK because their speed limits are ridiculous and change frequently. I racked up so much fine yesterday when driving in between their cities. Never had that issue with other European countries.
I think one of German cities is best as starting city (where your first garage will be located) due to its "central" position relative to other cities around it. Munich would be my choice but I am role playing a French female trucking company so I went with Metz.