Zombies now spawn loosely in the suburbs, but once you hit the market area, there will be swarms. AVOID SHOPS AT ALL COSTS. You'll probably want to be heavily equipped before you think about looting shops. The suburbs can handle most of your needs. I generally live in the suburbs, diving into a house, looting it, and hitting the next. I do that for days until I get a fairly good equipment set. Then I start to consider the inner city.
Right now it's day 11 and I still don't even have a gun.
Also, a suggestion for a different game mode. With the static spawns, there's now a chance to flesh out stealth game play, I think. Before zombies would just spawn randomly and it was impossible to hide from them.
For a rough idea, I would basically reduce the visual abilities of zombies significantly. Maybe like 16 tiles in every direction. This would be unaffected by night, making night more dangerous (as it should).
Hearing should be improved a bit, as to compensate for the lack of sight. If you fire a gun, you should expect a swarm.
Zombies would also be much, much more dangerous. They should be faster than you (without drugs) and do more damage than they do now, and have a higher accuracy. Specials would also be boosted accordingly. Hulks should be able to easily kill you single handedly at almost every stage of the game.
At the same time, zombies spawn rate should be decreased. I should be able to sneak into a market place, with maybe having to silently take out one or two zombies.
Finally, wildlife would be buffed. Wildlife should be more rare, but when you attract the attention of a cougar, you should be afraid if you don't have a firearm on you.
This is the rough idea, anyway. I'd mod it myself, but I don't know how to mod.