I'm only going to list stuff that hasn't been said before:
Rusty and Co. I'm just going to
quote TV Tropes here: "With the charismatic Mimic, absurdly cute rust monster Rusty, and the silent yet deadly Gelatinous Cube, the three set out in search of fame, fortune, and experience levels — and every level (adventure), they ally themselves with an Action Girl for at least part of the level.
"Of course, things that would be obstacles to more conventional adventurers pose no problem for these three, whereas other more simple tasks create great difficulties. Expect hilarity (with a side of Lampshade Hanging) to ensue."
Besides the main characters, the Action Girls are the best part. Madeline the Paladin is adorable and probably my favorite character.
Scandinavia and the World is a webcomic that imagines the countries of the world (especially the Scandinavian ones) as anthropomorphic personifications and portrays world in the context of their personal interactions. If you are familiar with Hetalia, I'm told it's sort of like that, except not limited to World War 2.
Overcompensating This may not be for everyone; it's the heavily fictionalized autobiographical account of Jeffrey Rowland, real life president of TopatoCo (the company that is responsible for producing merchandise for an number of webcomics, among them the Homestuck t-shirts) provides the topmost picture for wikipedia's article on loxoscelism (a condition caused by the bite of recluse spiders).
Wigu, a webcomic about a the strange adventures of a little boy named Wigu and his messed up family. The main project of Jeffrey Rowland and contains the namesake of TopatoCo.