Good grief, so many of the shows in here have awful anime art-styles.
I did quite like what I saw of F is For Family, though. It was perhaps a little weak but I could see it being more enjoyable as you get attached to the characters, even without it making any big changes between seasons... I'll have to watch s2 sometime!
I might check out Big Mouth sometime, too. Although I don't much like cheap crude humour or preachiness, and I'm not sure I'm that big a fan of shows in school settings either... whatever, I'll be sure to keep expectations low.
Since I'm posting in here, I want to recommend Final Space again.
At first glance it's just super-fun, over-the-top SPESS ADVENTURE, like the stream-of-consciousness ideas for action-packed space comics I'd come up with as a kid, but over time you realise it's actually very quite clever, with a lot of depth beneath its seemingly simple (or sometimes more on the surreal side) jokes.
Some guy named Olan Rogers voices the rambunctious, happy-go-lucky spaz of a main character. At first it seems like this guy could easily become irritating in the extreme, but in my experience at least he grew on me as the series possessed. The setting and graphics are all pretty sweet as well, again with the outwards cutesy-ness masking a surprising depth.
Also there's the occasional cat-person, for those of you who are into that kinda thing, and also a fair few jokes about assigning cute cat attributes to dangerous aliens for those of you who aren't.
Not sure what else I should say. It's on Netflix! Oh and it also stars David Tennant and Conan O'Brien in supporting roles.