It also happens to me some times, but it's calling me back again. I think the user interface is one of the top things in the game that really needs some optimizing. If simply "doing stuff" wasn't so complicated and cumbersome I'd bet money that the number of people who play the game would increase as would how often they come back to play more. Half the difficulty curve of Dwarf Fortress is dealing with the interface. How to use it, and finding out where things are and weird key bindings for some things. It's very time consuming and tedious at times.
My second most pressing issue is simply getting started. As in, getting a decent embark site. It really, REALLY sucks when you dump a bunch of time into a Fort only to find very little of interest as far as available materials, cave systems, or ambient beasties goes. A little more freedom in embark rules would be nice so you can customize your initial set up for challenges or just a simple change from the norm.
I really think Mineral Scarcity needs to be split into two settings. Diversity, and Vein size. As it is now, if it's highish, then you get resource starved or just a boring lack of variety. Too low and you get chaotic layers and veins of all kinds of stuff everywhere that doesn't "feel" right. Finding a good middle ground has been very difficult.