Imagine a new curse. This curse gives a random cursed person in worldgen an interaction. This interaction can target 2-3 targets of the same civ, then stops to work. The interaction give a syndrome, like fever, and give the ability to do the interaction as well.
Dwarf1 has fever. Infects dwarf 2 and 3 with fever. Dwarf 2 and 3 infect dwarf 4-7 with fever.
Then, after a certain time has passed, another syndrome actives in dwarf1. (by time delay) He can now do a similar interaction, just with a different syndrome attached. Vomit blood.
Then, after an even longer time, he unlocks another one, with necrosis. People start to die.
In this way modders could simulate sicknesses. A migrant arrives in your fortress, having this curse. He infects people with fever, no big problem. The player notices the fever epidemic, and starts a quarantine. After the sickness slows down/runs it natural course he can free the quarantined dwarves again. Many different sicknesses can be done, no limits. The flu ? The black death ? perpetual blindess that leaves a fortress of blind albino dwarves ? Magic hickups that turns people into sheep for a few ticks every now and then ? Mutations, making people stupid, but strong ? 28-days later rage-virus, zombiefications, hair and beard-loss ? All possible.
The major problem is balancing. I dont know how a medicine could be made, maybe by a boiling stone reaction that adds a creature class to people ? (possible?) Or a long lasting syndrome that adds resistance against the syndromes in the interaction ? "immunize dwarf against the flu" for example. I havent quite looked deep into it.
I hope this peaks some interested and several people will help, since I have no clue how complex/difficult this will get. I imagine it will be massive in the end. It would add much fun and complexity to the game, an entire new medical industry and could be added on its own to any game/mod out there.