Until you at least get fully covering clothes (which you don't get if you start with the most skill in some form of unarmed combat), you're at risk of getting serious injuries even from attacks by weak enemies. I actually had a wrestler get killed less than an hour in by having her throat torn open by a chimpanzee even as she was strangling it to death.
Stealth, thrown items (weapons, bolts, and rocks sharpened with knapping being probably the most effect readily available ones), and how to attack prone enemies are very important tactics.
Unfortunately, .12 has a bug where enemies with pathfind toward or away from you even if you're in hiding and .13 has a different bug where items thrown while in hiding keep going past everything until they hit the ground.
Against foes with melee weapons, attack with thrown items until they are killed or pass out from the pain and you can go in for the head crush "pinch" (remember you need to grab with a part with a hand to pinch, and thus have one free).
Foes with ranged weapons you'll want to sneak up to and disarm with wrestling (grab their weapon, gain control of it, then either put it into you inventory or throw it far away) then proceed as if facing a melee foe. Depending on your speed and ambushing skill, you may want to just avoid them entirely by running for cover and hiding.
Foes that are immune to pain or otherwise hard to disable you may wish to avoid until you're properly armored and very skilled.