Before my fortress fell apart from an unfortunate fish-related accident while draining a murky pool in the way of my fortress building, I experimented. I will try on my next attempt with the first level being simply defense and trading, the level above that will house the majority of my soldiers, the level below that will house goods ready for export.
Below that is the top level of my hotel blocks, which are 5 z-levels at peak, though I like to try and keep them to 3. 3 levels below the bottom housing level are the workshops, each of them have a basement twice it's length for storing input and output, and the workshops are separated by a hallway three tiles wide, which allows for an extra 3 tiles in their basements.
The workshops are 4x6, so I have two workshops per room, and an extra line of tiles for basement access. workshops are one z-level and basements are one z-level, so I can use the rest of the mountain for exploratory mining. The dining hall will have a food stockpile in it's center, and above that is a kitchen room with a furniture stockpile, two stills, two kitchens and a food stockpile, along with a stairway up to the farm level for easy access. Nobles and people who need larger bedrooms and offices/dining rooms/tombs will have their own separate hotel block assigned for them. Outside I'll work on building a moat without water on the ground level, to keep it from freezing and allowing access, and have a drawbridge there.
I wish I could find magma, a river and trees in the same embark map so I could work on a magma tunnel trap like the one in that other thread.