Yes, also, I can imagine holding something like a pike or a spear towards their mouth will likely impale them and completely screw up their swallow-game, going forward.
Really, actually swallowing something hole would generally be less effective than biting and shaking, which is actually currently in.
Anyhow, back to ideas, I think that enemies who are larger should have large contact areas for their attacks, and contact areas larger than a particular limb's cross section should also hit and distribute it's force against adjacent limbs. This means that, unless you're getting stomped, crushed, bent, or twisted apart, the injury from a giant enemy punching you is more likely to injure you by sending you flying and crashing into something, like into the ground or a tree or a wall, or your ally.
I can imagine big creatures could more easily restrain you by wrapping your whole body or most of it in an arm or hand, or as mentioned before, keep you pinned to the ground underfoot/body, whether deliberately injuring the person in question should depend on the attacker's intent.
For all these afformentioned attacks though, the really large creatures should probably more well telegraph their maneuvers, such that you could brace a pike towards their hand or stab it or jump out of the way before you're trapped, though if you don't fail the rolls too badly, you might have some hands (or at the very least, your teeth) free so that you can stab or bite at the assailing hand.