I'd suggest winebottler or something like that to play dwarf fortress. too much useful stuff happens on windowsland, sadly.
I'm using wineskin now
http://wineskin.doh123.com/
because it has a more recent version of wine, but you have to launch everything from the command line for it to work properly with multiple programs, a limitation that winebottler http://winebottler.kronenberg.org/ doesn't have
there are many other wine wrappers for mac. including a macport one.
If you're going to be running DF through Wine from commandline* anyway, get Macports and build the latest Wine development version (wine-devel) from there. Wine is one of the few programs of which I make sure to have the latest version at all times, because even small updates in Wine can fix a lot of issues in running Windows programs.
I personally recommend the
DIY DFG guide, which shows how to get the Mayday graphics set working on non-Windows copies of DF. It
should also apply generally to other graphics sets, but I haven't tested it personally on anything but the Mayday set.
*You could always make a small bash script to act as a shortcut, too... Something like this:
#!/bin/bash
cd path/to/df/folder
wine Dwarf\ Fortress.exe
(I cd to the DF folder first rather than going straight to Wine because sometimes that makes the program to look outside its local folder for its constituent files, which can cause it to fail)