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[Barnox]

Given that each world has its own procedural FB's, which their own syndromes, why not diseases?

Diseases would be gained from open wounds, in place of rot, or from a plant (in each world, the plant has its own syndrome).
As the plant is procedural, it may have thorns, which would inflict a creature interacting with it the syndrome.
Extracting from the plant would give a fluid with syndrome.

They would be cured by visiting a doctor, who would then clean it, and possibly apply a special cure ("Urist McDoctor determines this Urist McDiseased needs plump helmet salve!").

[Sean Mirrsen]

I'm generally a proponent of two things - procedural content and good spelling. The idea itself I like. The title? Not so much.

Procedural diseases could work seamlessly with curses and whatnot, as well. It'd be fun to have diseases or curses that do... odd things. Such as pushing your musicality down into the nether regions, or making your horns combust - if you have them. If you don't, it makes them grow, then combust.

[Barnox]

Hmm, I guess it could all work using the secrets/curses framework.
Some have a percentage of spreading on contact, whilst others would spread on looking at someone (to simulate being airborne).

The title was a genuine mistake: I can spell, honest.

[sockless]

I thought that it was planned to have them.