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[ChairmanPoo]

There's a reason why tissue typing is a thing, CP--  Even simple changes on cell membranes can ignite an autoimmune response. Hell, just inflammation can cause runaway autoimmune disorders, and that's not even a genetic cause.

Changes in the cell membrane are like-- Numero Uno on a white cell's hitlist for detecting things like cancer cells. If your receptor sites dont match the rest of your body, your immune system flags it as foreign, and starts tearing it down.

It's not that simple and it doesn't trigger that easy. There are tolerance systems in the body. It's even less likely that it would trigger a major response because of a minor change.  In fact, I daresay we know it doesn't, for there have been gene therapy trials for the last twenty years, and tissue rejection is not a major issue.



Secondary tumors are a more realistic concern, TBH, considering that it *did* happen.

[wierd]

No, really it is.

Autoinflammatory disease is TOTALLY a thing.

For many autoinflammatory processes, researchers have no clue as to what causes the initial inflammation.  Once the inflammation starts, it can progress into an autoimmune reaction when the body becomes sensitized to its own cell antigens. It then goes on the warpath, causing multiple organ failure in the most extreme cases.  (usually limited to a specific organ type though, like pancreatic cells, or bone cartilage)

Little things can and do set off the immune system.  There's drugs to mitigate this, like steroids, but those just knock down the inflammation temporarily. Off the drugs? Right back in a few days.

[ChairmanPoo]

I'm well aware that autoimmune diseases exist, thank you very much. What does that have to do with gene therapy? You're going off tangent.

[wierd]

Autoinflammatory != Autoimmune !!!!


They are related, but NOT the same thing! (You DID read the link right?)

Small things can trigger an autoinflammatory reaction, which can then trigger an autoimmune reaction. Small things, like having foreign cell antigens present.

[ChairmanPoo]

You're still going off tangent, (and onto a semantics debate to boot). Come up with data from clinical trials that suggests that either has been a serious, frequent complication of gene therapy, and you have a case.

(and no, before you ask, Jesse Gelsinger doesn't count)

[wierd]

Jesse had a reaction to the adenovirus, not the cell site receptor.

Also, these arent the kind of gene mods we are talking about. You are talking about thereputic gene mods, which dont change cell receptor proteins.  We are discussing mods that DO change cell receptor proteins.

The one on the tangent is you, demanding evidence for something that isnt done, because it would do bad things, and because it violates so many ethics considerations it makes my head swim.

The closest I can think of is the inter-species testicular cells grown in rats, from mouse progenitor cells. Naturally, they were rejected after taking root and producing mouse sperm cells, since they are from a completely different species.