I've got autism (featuring moderate-to-severe hypersensitivity problems) and bipolar disorder (Bipolar I, that is - Bipolar II is where you get really happy and energetic "hypomania." I have the paranoid, delusional, extreme panic and anxiety kind where I think the people around me are reptilian monsters who want to eat my skin, though fortunately it only happens about once every few years, with the occasional bout of major depression in between). I also almost certainly have mild-to-moderate narcolepsy, but the diagnosis for that is too expensive and takes too much time for me to get it done for now. I might manage it during the summer.
Surprisingly, I have a pretty good life and I'm mostly pretty happy, or at least content. It sounds silly, but actually the wisdom of vulcan philosophy helps a lot to deal with my problems. When I start to get overwhelmed due to sensory issues or paranoia or what have you, Imaginary Spock comes along and helps me analyze the situation in a detached way, and most of the time I can get through it without any major incidents. I've tried a few different medications, but they all resulted in really horrific side effects (and two of them actually triggered attacks of mania), so now I just deal with things without meds, and fortunately it's working out okay so far.